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Alpha Hydroxy Acid (AHA)

Alpha-Hydroxy Acid (AHA) Effects in the Skin

What It Is: Glycolic acid, lactic acid, and mandelic acid are the most common alpha hydroxy acids used in skin care formulations, in creams and gels in 10% or lower strength. For all intents and purposes, glycolic acid is the type you will likely find at a drugstore. (Learn more on the glycolic acid page of

What It Does: Alpha hydroxy acids chemically exfoliate the surface of the skin. This signals the skin to increase cell turnover, which can help existing acne lesions heal faster and can help pores from becoming clogged moving forward.1-4 The exfoliation produced by alpha hydroxy acids also helps alleviate dry, flaky skin. Because AHAs will not completely clear the skin on their own, they are best used with other medications. They are known to “turbo-charge” other medications and make them work better.

Considerations: Mild side effects may include stinging and redness. Because alpha hydroxy acid removes the surface layers of skin cells, the skin can become more susceptible to sunburn in the days following use.5 Be certain to protect your skin with an effective sunscreen when using alpha hydroxy acid containing products and for a week afterward.

Chemical peels in percentages higher than 10% must be administered professionally.

Benzoyl Peroxide

Benzoyl Peroxide Effects in the Skin

What It Is: The FDA allows benzoyl peroxide to be sold by prescription or over-the-counter, in concentrations from 2.5% to 10%, in cream, gel, and wash form. When used properly, it is the most effective treatment for acne. (Learn more from the U.S. National Library of Medicine)

What It Does: Benzoyl peroxide penetrates the skin, where it kills acne bacteria. Also, there is a mild drying and peeling effect which is thought to help prevent breakouts.6-10 Benzoyl peroxide also may help lessen inflammation.11-13 2.5% benzoyl peroxide is just as effective as higher concentrations with less side effects.10,14

Considerations: Some dryness, redness, and itchiness is to be expected, especially in the first few weeks of use.10,15 About 1 in 500 people are allergic to benzoyl peroxide and experience swelling of the skin or severe crusting, and in that case should stop using it immediately.16

Benzoyl peroxide can bleach hair and fabric.6


Resorcinol Effects in the Skin

What It Is: Resorcinol is used to treat acne, but also eczema and psoriasis among other skin conditions. It is sometimes combined with other acne medications, usually sulfur, and rarely stands alone.17 (Learn more from Wikipedia)

What It Does: Resorcinol helps break down hard, rough skin, which means it is good at breaking down existing blackheads and whiteheads.17,18

Considerations: Because it is already potentially irritating, sometimes causing redness or peeling of the skin, it is good to avoid other irritating soaps and cleansers, astringents or alcohol products, and also other medications.17

Salicylic Acid

Salicylic Acid Effects in the Skin

What It Is: Salicylic acid is an ingredient used in many over-the-counter acne medications at concentrations from 0.5% to 2%.19 As of 2022, a third of the most popular over-the-counter acne products sold in the U.S. contains salicylic acid, making it the most common anti-acne ingredient.20 Salicylic acid is often sold with pads as applicators (such as Stri-dex® pads). It is also used to treat other skin disorders including dandruff, psoriasis, calluses, corns, warts, and more.21-23 (Learn more from the U.S. National Library of Medicine)

What It Does: Acne is formed when skin cells inside hair follicles accumulate and clump together, plugging up the follicle and causing a pimple. Salicylic acid helps limit this accumulation of skin cells, which can help prevent clogging. Salicylic acid also helps break down blackheads and whiteheads.22,23

Considerations: Certain salicylic acid-containing products may be irritating when used with other over-the-counter medications, and people often report a mild stinging when applying the product..22 Results are moderate at best, and therefore salicylic acid is often combined with other medications for best results.


What It Is: Sulfur has been used to treat acne for thousands of years for its peeling and drying actions and is found in various washes, soaps, and creams. Because it has a disagreeable odor and can temporarily discolor the skin, it is often combined with other medications such as benzoyl peroxide or sodium sulfacetamide to reduce these unpleasant characteristics.24,25 (Learn more from Wikipedia)

What It Does: Sulfur provides peeling and drying of the skin, and can help break down existing blackheads and whiteheads. It is also bacteriostatic, which means while it does not kill acne bacteria, it can limit the growth of acne bacteria.24-27

Considerations: It smells bad. It may also temporarily discolor skin. Side effects include peeling and redness and occasional fissures around the mouth, but overall sulfur is well tolerated.28

Allergy to sulfur itself is extremely rare, but sulfur is often combined with sodium sulfacetamide, and allergy to sodium sulfacetamide is much more common, affecting around 3% of people. Medications that combine sulfur and sodium sulfacetamide should not be used by people with allergies to sulfa drugs.29-31

It is advised that women planning to become pregnant, pregnant, or lactating speak with their physician before using sulfur.32

Combining Over-the-counter Ingredients

Acne is a complex disease, so a combination of anti-acne ingredients might be more effective than any one ingredient by itself. For example, research suggests that it might be useful to combine antibacterial ingredients like benzoyl peroxide with skin-peeling ingredients like glycolic acid.33,34

How to Wash Your Face

Whatever medication you decide to use, it is important to properly wash your skin before treating.

Wash your face only twice per day, morning and evening. Excess washing can cause irritation.

Use only your bare hands to wash, and wash for 10 seconds or less. Washcloths and hand-held cleansing devices are unnecessarily irritating. Consider the act of washing as simply prepping your skin for medication, nothing more. Washing itself does not clear breakouts since dirt does not cause acne, so there is absolutely no need to scrub.

Pat dry. Do not rub dry. Rubbing the skin is irritating, and excess irritation can perpetuate the acne cycle. Gently pat dry.

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  16. Lindemayr, H. & Drobil M. Contact Sensitization to Benzoyl Peroxide. Contact Dermatitis. 7, 137-40 (1981).
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  18. Resorcinol Topical. 2010. Cerner Multum, Inc. 1996-2006.
  19. Questions and Answers About Acne. National Institute of Arthritis and Musculoskeletal and Skin Diseases. 2010. National Institutes of Health. 2011.
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  21. Shalita, A. Comparison of a salicylic acid cleanser and a benzoyl peroxide wash in treatment of acne vulgaris. Clin. Ther. 11, 264-267 (1989).
  22. Salicylic Acid Topical. MedlinePlus. 2010. American Society of Health System Pharmacists, Inc. 2011.
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